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by strongmama
Tue Jan 08, 2019 4:18 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Keytruda....Working for MSS....Mutation Burden is the Key
Replies: 152
Views: 45322

Re: Keytruda....Working for MSS....Mutation Burden is the Key

Cynthia it looks like you've had radiation? The person I mentioned with 13 TMB said there were a couple of other responders on her trial. Besides being MSS with intermediate TMB they all had Y-90.... so they suspect something with radiation may have helped. What are your thoughts on this? Have you h...
by strongmama
Sun Jan 06, 2019 2:43 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Keytruda....Working for MSS....Mutation Burden is the Key
Replies: 152
Views: 45322

Re: Keytruda....Working for MSS....Mutation Burden is the Key

Hi Cynthia! Thank you for your reply!! I believe TMB is a factor as well. I have read of MSS patients with high TMB having response and there seems to be research supporting this, but I have not come across as much about intermediate TMB. My daughter is stage 4 and has a TMB of 12 so we are planning...
by strongmama
Wed Jan 02, 2019 9:11 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Keytruda....Working for MSS....Mutation Burden is the Key
Replies: 152
Views: 45322

Re: Keytruda....Working for MSS....Mutation Burden is the Key

Are there any other MSS people here with intermediate TMB having good results on Keytruda or Opdivo? Cynthia how long have you been on Keytruda? I've heard that being intermediate and either on Keto or having low blood surgar may help. Would you say that could be a factor for you? One person I know ...

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