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by NHMike
Thu Nov 23, 2017 10:16 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: NRAS Q61R - what does that mean?
Replies: 3
Views: 39

Re: NRAS Q61R - what does that mean?

I'm sorry for the difficulties that your mother is going through and hope that those two posts provide a bit more information about NRAS, and her particular mutation. From what I understand, the whole NRAS Gene mutation set tends to worse prognosis. NRAS isn't common so it seems that we're still a b...
by NHMike
Thu Nov 23, 2017 10:10 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: NRAS Q61R - what does that mean?
Replies: 3
Views: 39

Re: NRAS Q61R - what does that mean?

Frequency of NRAS mutations in colorectal cancer: 1–6% of colorectal cancers (COSMIC; De Roock et al. 2010; Irahara et al. 2009; Janku et al. 2007; Vaughn et al. 2011)​​ Frequency of Q61R among NRAS-mutated colorectal cancers: 16.8% (COSMIC) https://www.mycancergenome.org/content/disease/colorectal-...
by NHMike
Thu Nov 23, 2017 10:05 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: NRAS Q61R - what does that mean?
Replies: 3
Views: 39

Re: NRAS Q61R - what does that mean?

NRAS is a gene that provides the code for making NRAS, a GTPase that converts GTP to GDP. This protein is part of the MAP kinase signaling cascade that relays chemical signals from the outside of the cell to the cell's nucleus, and is primarily involved in controlling cell division. When NRAS is at...
by NHMike
Thu Nov 23, 2017 10:04 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: KRAS G12V Mutation Question
Replies: 20
Views: 448

Re: KRAS G12V Mutation Question

I don't know if this will help. It won't directly answer your question but it might approach it from another angle. I just learned that my tumor (removed over a year ago) had a KRAS 13 mutation. I've been on chemo for over a year and I was in a pretty dark place a while back; the chemo - everything...
by NHMike
Thu Nov 23, 2017 9:59 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: KRAS G12V Mutation Question
Replies: 20
Views: 448

Re: KRAS G12V Mutation Question

This paper's results had G12V as the marker of the most successfully treated line (SW480) )of the mutant CRC cell lines tested (vs LoVo for KRAS G13D and HT29 for BRAF V600E), for mutant CRC cells treated with vitamin C. IV vitamin C temporarily reaches much higher levels in the arteries and veins ...
by NHMike
Wed Nov 22, 2017 2:47 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: KRAS G12V Mutation Question
Replies: 20
Views: 448

Re: KRAS G12V Mutation Question

I thought that KRAS G12V was more or less the same as the other G12* mutations but it's associated with worse prognosis. A person posted that his wife has this mutation this morning and the prognosis doesn't sound good. I did a search on the forum for G12V and a few of Maia's posts came up for clini...
by NHMike
Wed Nov 22, 2017 10:36 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: 33 year old - Stage 4 - no family history
Replies: 13
Views: 353

Re: 33 year old - Stage 4 - no family history

Lynch Syndrome, MYH-Associated Polyposis, and Hyperplastic Polyposis Syndrome are all inherited types of colon cancer so you're not likely to have them since you have no family history. However, get tested anyway to make sure. Other genetic tests you should have include: KRAS, BRAF, MLH1, MSH2, APC...
by NHMike
Wed Nov 22, 2017 10:25 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: 33 year old - Stage 4 - no family history
Replies: 13
Views: 353

Re: 33 year old - Stage 4 - no family history

2) I'm young, have no co-morbidities, and have spent much of this year in unbelievable agony. Treatment is tolerated differently by everyone, and I'm glad you're doing well, but I've been told "but you're young and look good!" so many times when I've wanted to just die already, that the s...
by NHMike
Wed Nov 22, 2017 7:46 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Update: It's just a matter of time
Replies: 12
Views: 445

Re: Update: It's just a matter of time

I'm very sorry to hear about your wife as I also have a KRAS mutation. I looked up G12V at https://targetedcancercare.massgeneral.org/My-Trial-Guide/Diseases/Colorectal-Cancer/KRAS/G12V-(c-35G-T).aspx and see the paragraph: There is no clear association between activating KRAS mutations and poor pro...
by NHMike
Wed Nov 22, 2017 7:41 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: O/T The 4 Kinds Of Health Chatroom Users (Article)
Replies: 5
Views: 121

Re: O/T The 4 Kinds Of Health Chatroom Users (Article)

I'm not a participant of the survey but I think our group is unlike any other. I have tried to join a group for Meniers disease and TNA, but both were non funtional. Also, I despise surveys. I am the jerk who chooses the middle answer for every question just to be difficult. I am always annoyed the...
by NHMike
Tue Nov 21, 2017 9:40 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Just finished treatment
Replies: 4
Views: 156

Re: Just finished treatment

It took me one to two weeks for the radiation burns to go away. I think that it took that long to get my energy back too.
by NHMike
Tue Nov 21, 2017 7:09 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Rectal cancer (Stage 3A) diagnosed late June 2017
Replies: 366
Views: 30214

Re: Rectal cancer (Stage 3A) diagnosed late June 2017

Three hours is quite a long time to be sitting at the hospital or infusion center. Sounds like something I'd want to do relatively local.
by NHMike
Tue Nov 21, 2017 5:28 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Rectal cancer (Stage 3A) diagnosed late June 2017
Replies: 366
Views: 30214

Re: Rectal cancer (Stage 3A) diagnosed late June 2017

My Ileostomy supplies arrived and they're the right ones this time. So I'm good for at least a month. If I maintain five days per wafer/bag, I'm good for 125 days with these and my hospital supplies. I'll order another batch in December though in case the reversal doesn't go according to plan (suppo...
by NHMike
Tue Nov 21, 2017 3:40 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: 33 year old - Stage 4 - no family history
Replies: 13
Views: 353

Re: 33 year old - Stage 4 - no family history

MSI-H can be determined by ImmunoHistoChemistry testing which insurance companies will cover more easily than genomic testing. The IHC testing should be standard practice on a biopsy with a colonoscopy (that's what they did to me). I think that genomic testing of the tumor is a good idea but I think...

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