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by mpbser
Sat Jul 13, 2019 5:12 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: My CRC with liver mets journey
Replies: 177
Views: 22756

Re: My CRC with liver mets journey

Just popping in to say that I caught up with this thread and can completely relate to the work issues you've described. I think Maggie Nell hit the nail on the head with her analysis. My husband's boss feels like a ship without a sail and a fish without water whenever my husband needs to take time o...
by mpbser
Thu Jul 11, 2019 10:53 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Red cell distribution width
Replies: 1
Views: 195

Re: Red cell distribution width

I just read this, which makes me think that the residual scrotal hematoma (STILL hasn't completely resolved!) is causing the RDW to be slightly elevated: hemolysis or blood transfusion can also cause an elevated RDW. But I like to double-check everything -- as stated on another thread, better to be ...
by mpbser
Thu Jul 11, 2019 10:47 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Red cell distribution width
Replies: 1
Views: 195

Red cell distribution width

I recently noticed that my husband's red cell distribution width (RDW) has been elevated since May 15th (HAI pump crisis time). Curious as to what that might mean, I found very scary data about it. This factoid stands out in particular: "RDW was strongly associated with deaths from cancer."...
by mpbser
Thu Jul 11, 2019 10:04 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Stage IV (with liver cyst) - 6 yrs NED
Replies: 10
Views: 953

Re: Stage IV (with liver cyst) - 6 yrs NED

I consider cysts to be much like lymph nodes in regard to growth and shrinkage. My husband has a 2.3 cm x 1.6 cm periportal node that has me anxious. The radiologist called it "stable" but I don't like the fact that it's now 2.3 cm x 1.6 cm when it was 2.0 x 1.1 cm in December 2018. That b...
by mpbser
Wed Jun 26, 2019 12:34 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Image of lymph node v of liver met on MRI
Replies: 2
Views: 392

Image of lymph node v of liver met on MRI

Here is a question that I know will take me an inordinate amount of time to find an answer to online, so I thought I would throw it out here to the group to see if anyone may have answers: Does an MRI image of a cancerous lymph node, e.g. periportal or portocaval (aka portacaval), have the same char...
by mpbser
Thu Jun 20, 2019 5:10 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Currently in the ER...woo.
Replies: 56
Views: 2714

Re: Currently in the ER...woo.

Thinking of you and sending vibes/prayers
by mpbser
Sun Jun 16, 2019 5:18 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Stage IV (with liver cyst) - 6 yrs NED
Replies: 10
Views: 953

Re: Stage IV (with liver cyst) - 6 yrs NED

Has it ever been biopsied? My husband has (and had) a number of cysts (actually benign tumors called hamartomas) on his liver. We know they aren't cancerous because all have been biopsied. If yours hasn't been biopsied, the one characteristic that distinguished his benign masses from the cancerous o...
by mpbser
Sat Jun 15, 2019 5:46 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Our Miss Molly/Karen going into hospice
Replies: 45
Views: 4900

Re: Our Miss Molly/Karen going into hospice

Thank you for the update. I am glad to hear she is getting treated.
by mpbser
Fri Jun 14, 2019 6:56 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: 5FU as second line?
Replies: 12
Views: 866

Re: 5FU as second line?

Looking at that article you shared, julie, and see that "Significant resistance to 5-FU resulted from p53-loss or from gain-of-function (GOF) mutation (R248W)." My husband's mutation is [at least in the "first primary colon tumor"] "TP53 c.745A>G (p.R249G), exon 7 - in 34% o...
by mpbser
Fri Jun 14, 2019 6:29 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: 5FU as second line?
Replies: 12
Views: 866

Re: 5FU as second line?

Who would have thought that it could get even more complicated??? [/sarcasm]

Thanks for sharing. I look forward to spending the weekend reading about this and 5FU monotherapy. [/not sarcasm]

My husband's tp53 mutation was at exon 7. I'm not sure if that is a good or bad thing.
by mpbser
Thu Jun 13, 2019 12:34 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: 5FU as second line?
Replies: 12
Views: 866

Re: 5FU as second line?

Julie, Do you happen to know if your CC was tp53 mutated? I read, again as I have seen this expressed a number of times in various journal articles over the past couple years, that "CRC with mutated TP53 is resistant to 5-FU" in this extremely interesting article https://www.ncbi.nlm.nih.g...
by mpbser
Thu Jun 13, 2019 5:59 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: HELP. Mother’s treatment wrong?
Replies: 6
Views: 503

Re: HELP. Mother’s treatment wrong?

I LOVE all your questions. They tell me that you are paying close attention and caring about your mom. Here are my responses: - she’s being treated exclusively by general surgeon. She had informal mtg w oncologist when she was in the emergency room after the colonoscopy. As it was an emergency surge...
by mpbser
Wed Jun 12, 2019 4:02 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: 5FU as second line?
Replies: 12
Views: 866

Re: 5FU as second line?

No, I hadn't seen that. Thanks, LPL! I am familiar with the sad statistics cited in that website: even with the addition of leucovorin, only about 20 percent of mCRC patients respond to treatment, compared to approximately 10 percent response to 5-FU alone (J Clin Oncol 1989;7:1419-1426)... oxalipla...
by mpbser
Wed Jun 12, 2019 8:15 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Another 6 months
Replies: 13
Views: 791

Re: Another 6 months

Awesome!
by mpbser
Wed Jun 12, 2019 5:30 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: On a Clinical Trial but I Think We're Reaching the End
Replies: 17
Views: 1503

Re: On a Clinical Trial but I Think We're Reaching the End

inorganic,

sending you positive vibes. You have been in my thoughts

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