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by sdino
Fri Jun 08, 2018 10:33 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Signs of travelling to lungs?
Replies: 10
Views: 687

Re: Signs of travelling to lungs?

when my Wife had her first Colonoscopy, they found the cancerous tumor in Sigmoid Colon. Our GI Dr. ordered an abdominal CT scan. Most abdominal CT scans catch the lower portion of your lungs, hence that's where they found some nodules. Also, I just had an abdominal CT scans last week for some urine...
by sdino
Fri Jun 08, 2018 10:25 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: anyone here with Kras T53 mutation
Replies: 16
Views: 457

Re: anyone here with Kras T53 mutation

Here is my take on the TP53's: So... Healthy P53’s fight cancerous DNA. But when they get sick or mutated they stop fighting the bad cells. So there is efforts to boost the healthy P53’s to fight harder but years of testing, nothing has made it to the Market. Researchers are trying to restore the P5...
by sdino
Wed May 09, 2018 8:29 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Path report - kras and tp53
Replies: 4
Views: 388

Re: Path report - kras and tp53

Here is my take on a article I read on TP53: So... Healthy P53’s fight cancerous DNA. But when they get sick or mutated they stop fighting the bad cells. So there is efforts to boost the healthy P53’s to fight harder but years of testing, nothing has made it to the Market. Researchers are trying to ...
by sdino
Wed May 09, 2018 6:48 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Teri's TIL trial at NCI
Replies: 10
Views: 542

Re: Teri's TIL trial at NCI

Great news !
by sdino
Mon Apr 23, 2018 11:37 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: TIL trial at NIH going for initial testing
Replies: 8
Views: 1253

Re: TIL trial at NIH going for initial testing

Hi teri3 - In my general laymen terms - Typically the NCI Team will review all your results, they have a meeting the following Monday and make a decision if you’re a good candidate for the trial or not. Also, If it’s a go, they will request you to be off Chemo at least 30 days prior to surgery. Surg...
by sdino
Tue Apr 10, 2018 7:04 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: New TIL Trial NIH/NCI NCT03412877
Replies: 4
Views: 739

Re: New TIL Trial NIH/NCI NCT03412877

Thanks DH2, Great explanation. and yes, it does take longer to develop these Young TILs, so NCI reviews your disease progress very closely to ensure they do not put you at risk.
by sdino
Mon Apr 09, 2018 1:10 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: New TIL Trial NIH/NCI NCT03412877
Replies: 4
Views: 739

New TIL Trial NIH/NCI NCT03412877

New TIL trial at NCI/NIH with Dr. Rosenberg as lead investigator opened this month. https://clinicaltrials.gov/ct2/show/NCT03412877
by sdino
Mon Mar 12, 2018 7:05 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: TIL Immunotherapy at NCI
Replies: 591
Views: 105277

Re: TIL Immunotherapy at NCI

Hi Sharijohn - We are still awaiting word from NCI/NIH if her TIL cells are reactive in the lab. Should know something within the next 2 weeks or so... Steps and timelines after TIL harvest Surgery: 1. After TIL Harvest Surgery = 2 to 3 weeks if cells are growing by the billions. 2. After TIL Harves...
by sdino
Wed Feb 07, 2018 9:46 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: STAGE IV KRAS G12V NON MSI-HIGH
Replies: 3
Views: 536

Re: STAGE IV KRAS G12V NON MSI-HIGH

Hi sharijohn - these 3 trials might be of interest for you: NCT02079740 - To determine the response rate of the combination of trametinib and navitoclax in subjects with KRAS or NRAS mutation-positive advanced or metastatic solid tumors in disease-specific expansion cohorts. (Phase II) III. To confi...
by sdino
Fri Feb 02, 2018 7:51 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: TIL Immunotherapy at NCI
Replies: 591
Views: 105277

Re: TIL Immunotherapy at NCI

What I found on "Young" TILs - This led to the development by Dudley et al in 2010 of a streamlined “Young TIL” protocol that pools lymphocytes from multiple tumor fragments, without additional selection, to obtain the cell number needed prior to rapid expansion, shortening the time compar...
by sdino
Thu Jan 11, 2018 12:19 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: TIL Immunotherapy at NCI
Replies: 591
Views: 105277

Re: TIL Immunotherapy at NCI

My Wife had lung wedge resection surgery this week 1/8/18 at NCI/NIH to harvest her TILs. Everything went well and today we will go home after she completes Aspheresis. Now we wait and see for 3 months if the harvested cells grow with the proper mutations. Incredible stuff going on down here in Beth...
by sdino
Mon Dec 18, 2017 9:54 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: At Slight Crossroads and NCT01174121
Replies: 15
Views: 1762

Re: At Slight Crossroads and NCT01174121

My Wife has been accepted into the trial. Surgery to resect lung mets slated for Jan 10th.
by sdino
Sat Dec 16, 2017 10:21 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: At Slight Crossroads and NCT01174121
Replies: 15
Views: 1762

Re: At Slight Crossroads and NCT01174121

The crossroads has been .... CROSSED. We visited NCI/NIH last week for prescreening processes (Brain MRI, Blood work, pul function test, CT scan(s) review, chest Xray, exams), met with the Clinical Nurses- RN's Nixon and McIntyre, Fellow Dr Shindorf, Dr Yang-Lead doctor and Surgeon Dr Ripley - All F...
by sdino
Sun Dec 10, 2017 8:31 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: TIL Immunotherapy at NCI
Replies: 591
Views: 105277

Re: TIL Immunotherapy at NCI

My Wife's was a Blood Test for HLA
by sdino
Sun Dec 03, 2017 12:25 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Anyone with Stage IVa just do Xelolda or 5-fu?
Replies: 90
Views: 8863

Re: Anyone with Stage IVa just do Xelolda or 5-fu?

Wife was on Xeloda (3000 mg/day) + Avastin IV since 8/2/17. Been through 6 full treatments. CT scan showed slight growth in lung mets.

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