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by LMighty
Tue Jul 25, 2017 12:48 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: TECENTRIQ (atezolizumab) + COTELLIC (cobimetinib) for Stage IV, starting 11/7/2017
Replies: 13
Views: 715

Re: TECENTRIQ (atezolizumab) + COTELLIC (cobimetinib) for Stage IV, starting 11/7/2017

Update #2: It has been 2 weeks since the start of the new regimen. Today's X-ray showed slight decrease of shadowy area in both lungs. Our onc said it's a very positive and miraculous response considering we are only 2 weeks in! Fluids seem to build up again in the lungs and abdomen but at a much sl...
by LMighty
Thu Jul 20, 2017 12:13 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Fluid on the lung???
Replies: 6
Views: 502

Re: Fluid on the lung???

My mom has been battling pleural effusion since last year. The fluid accumulates when the the disease grows in the pleural space. It comes back until you treat the underlying disease. A procedure called pleurodesis (https://en.wikipedia.org/wiki/Pleurodesis) may prevent its recurrence. It basically ...
by LMighty
Sat Jul 15, 2017 8:40 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: TECENTRIQ (atezolizumab) + COTELLIC (cobimetinib) for Stage IV, starting 11/7/2017
Replies: 13
Views: 715

Re: TECENTRIQ (atezolizumab) + COTELLIC (cobimetinib) for Stage IV, starting 11/7/2017

LMighty, so happy to hear! An actual step in the right direction! Is your mom feeling more comfortable now? Not needing the drainage is itself such a relief. Yes she is. Her energy level is slowly recovering with the help of low dose of supplementary oxygen. She has intestinal cramps and mild diahh...
by LMighty
Fri Jul 14, 2017 3:49 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: TECENTRIQ (atezolizumab) + COTELLIC (cobimetinib) for Stage IV, starting 11/7/2017
Replies: 13
Views: 715

Re: TECENTRIQ (atezolizumab) + COTELLIC (cobimetinib) for Stage IV, starting 11/7/2017

Hi everyone, Thank you so much for your kind words! I have an encouraging update. Since Wednesday the ascites reduced from 300-500ml daily to virtually zero. Not even detectable by ultrasound. Our onc said it's good news but it's too early to tell if it represents response. We will see if it stays t...
by LMighty
Tue Jul 11, 2017 9:43 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: TECENTRIQ (atezolizumab) + COTELLIC (cobimetinib) for Stage IV, starting 11/7/2017
Replies: 13
Views: 715

Re: TECENTRIQ (atezolizumab) + COTELLIC (cobimetinib) for Stage IV, starting 11/7/2017

Hey Maia, Thanks for your concern! My mom is still in hospital for pleural fluid and ascites drainage and it has been a month. We are leaving the drains in so we can remove the fluid at home. X-rays from a few days ago showed a bit more shadow especially in the left lung. Our onc's interpretation is...
by LMighty
Tue Jul 11, 2017 3:36 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: TECENTRIQ (atezolizumab) + COTELLIC (cobimetinib) for Stage IV, starting 11/7/2017
Replies: 13
Views: 715

TECENTRIQ (atezolizumab) + COTELLIC (cobimetinib) for Stage IV, starting 11/7/2017

HI everyone, With the help and support from members on this board (particularly Maia -- the info you shared is crucial!) and our VERY accommodating, supportive oncologist, treatment with TECENTRIQ (atezolizumab) + COTELLIC (cobimetinib) for my mom (stage IV, KRAS wild-type, MSS; failed Xelox + Avast...
by LMighty
Fri Jun 30, 2017 1:19 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Ascites. Peritoneal mets confirmed.
Replies: 34
Views: 4821

Re: Ascites. Peritoneal mets confirmed.

UPDATE: We finally secured supply of both Tecentriq and Cotellic (very expensive of course) and the treatment will start in a few days. I may create a dedicated thread soon as I am sure many members of this board would be interested.
by LMighty
Tue Jun 27, 2017 3:54 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Ascites. Peritoneal mets confirmed.
Replies: 34
Views: 4821

Re: Ascites. Peritoneal mets confirmed.

My mom is MSS so the only option left for her is combining Keytruda with Cotellic and Tecentriq--if we can get them, that is. Our onc is working on that. Most likely he can only get Cotellic though. Keytruda and Tecentriq are almost equivalent --an anti PD-1 and an anti PD-L1, respectively. One use...
by LMighty
Sun Jun 25, 2017 10:31 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Ascites. Peritoneal mets confirmed.
Replies: 34
Views: 4821

Re: Ascites. Peritoneal mets confirmed.

Bad news. MS status finally confirmed. My mom is MSS so the only option left for her is combining Keytruda with Cotellic and Tecentriq--if we can get them, that is. Our onc is working on that. Most likely he can only get Cotellic though.

Anyhow, we are not giving up.
by LMighty
Tue Jun 20, 2017 3:45 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: The grueling wait for response to Keytruda (with MS status unconfirmed)
Replies: 4
Views: 457

Re: The grueling wait for response to Keytruda (with MS status unconfirmed)

The pericardial effusion turned out to be false, confirmed by further scan. What an unhealthy amount of scare.
by LMighty
Mon Jun 19, 2017 2:23 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: The grueling wait for response to Keytruda (with MS status unconfirmed)
Replies: 4
Views: 457

Re: The grueling wait for response to Keytruda (with MS status unconfirmed)

Maia, thank you for your kind words. Unfortunately my mom has pericardial effusion just now. No immediate danger but certainly life threatening. Our onc mentioned hospice as an option as frequent tapping from multiple sites (heart, lungs and abdomen) could be quite a suffering. We are not giving up ...
by LMighty
Sun Jun 18, 2017 4:46 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: The grueling wait for response to Keytruda (with MS status unconfirmed)
Replies: 4
Views: 457

The grueling wait for response to Keytruda (with MS status unconfirmed)

Hate to be a downer but I really need to vent. So after my mom had her first shot of Keytruda on 5 June, she was hospitalized 4 times for pleural fluid and/or ascites tapping. The fluids in both sites reaccumulated rapidly as if actually worsened by Keytruda or progression. So rapid (~800 ml daily) ...
by LMighty
Thu Jun 15, 2017 11:37 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Things Not to Say and the Responses I want to Make (Rant)
Replies: 113
Views: 8513

Re: Things Not to Say and the Responses I want to Make (Rant)

I am at the hostipal with my mom who is having pleural fluid and ascites tap. This lady next to us, she was hospitalized to treat symptoms from some advanced cancer. We overheard that the lady refused conventional treatment and turned to TCM instead, without consulting any TCM practitioner but Dr. G...
by LMighty
Wed Jun 14, 2017 11:12 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Beansmama Checking in
Replies: 34
Views: 3881

Re: Beansmama Checking in

BeansMama,

Really sorry to hear the situation you are going through but delighted to know treatment goes well. Your strength is inspiring and I hope things get better and better for you!

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