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by LMighty
Wed Aug 09, 2017 11:49 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: TECENTRIQ (atezolizumab) + COTELLIC (cobimetinib) for Stage IV, starting 11/7/2017
Replies: 24
Views: 2570

Re: TECENTRIQ (atezolizumab) + COTELLIC (cobimetinib) for Stage IV, starting 11/7/2017

Update #6: The second treatement cycle was supposed to start yesterday but my mom recently developed rapid heart rate (110+ resting), shortness of breath and extreme fatigue, with visibly swollen legs and sudden increase in ascites. The treatment was delayed. Doctors suspected deep vein thrombosis i...
by LMighty
Tue Aug 01, 2017 11:12 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: BREAKING: Nivolumab (Opdivo) APPROVED for MSI-High CRC
Replies: 6
Views: 321

Re: BREAKING: Nivolumab (Opdivo) APPROVED for MSI-High CRC

Another monumental progress! Hope more good news for MSS soon.
by LMighty
Tue Aug 01, 2017 11:10 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: TECENTRIQ (atezolizumab) + COTELLIC (cobimetinib) for Stage IV, starting 11/7/2017
Replies: 24
Views: 2570

Re: TECENTRIQ (atezolizumab) + COTELLIC (cobimetinib) for Stage IV, starting 11/7/2017

Hi everyone, Update #5: Today my mom is 3 weeks in with TECENTRIQ + COTELLIC. It marks the completion of the first cycle of treatment (biweekly infusion of TECENTRIQ + 3 weeks of COTELLIC taken orally). She will now take a break for a week, or a few days more if needed. Starting yesterday her restin...
by LMighty
Sat Jul 29, 2017 9:05 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: TECENTRIQ (atezolizumab) + COTELLIC (cobimetinib) for Stage IV, starting 11/7/2017
Replies: 24
Views: 2570

Re: TECENTRIQ (atezolizumab) + COTELLIC (cobimetinib) for Stage IV, starting 11/7/2017

Hi Maia,

It went back down to around 200ml yesterday. This is so confusing. Maybe we should not be worried after all...

Onc will be back from vacation tomorrow. Let's see how he thinks.
by LMighty
Fri Jul 28, 2017 7:03 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: TECENTRIQ (atezolizumab) + COTELLIC (cobimetinib) for Stage IV, starting 11/7/2017
Replies: 24
Views: 2570

Re: TECENTRIQ (atezolizumab) + COTELLIC (cobimetinib) for Stage IV, starting 11/7/2017

Update #4: Ascites comes back in a manner almost like a revenge. Drained about 800ml yesterday. Not sure if we should be worried as it may be due to hypothyroidism-induced fluid retention.
by LMighty
Thu Jul 27, 2017 11:50 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: TECENTRIQ (atezolizumab) + COTELLIC (cobimetinib) for Stage IV, starting 11/7/2017
Replies: 24
Views: 2570

Re: TECENTRIQ (atezolizumab) + COTELLIC (cobimetinib) for Stage IV, starting 11/7/2017

Maia wrote:Fever ---and the thyroid disorder-- sound like side effects from the immunotherapy.


BTW to be exact the thyroid disorder seems to be hypothyroidism.
by LMighty
Thu Jul 27, 2017 11:48 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: TECENTRIQ (atezolizumab) + COTELLIC (cobimetinib) for Stage IV, starting 11/7/2017
Replies: 24
Views: 2570

Re: TECENTRIQ (atezolizumab) + COTELLIC (cobimetinib) for Stage IV, starting 11/7/2017

Thanks Maia for the additional info! Our onc keep saying the ascites and pleural fluid are the result of rapid death of cancer cell. I am not sure how that works but I do hope that is what's happening. It also seems that the fluids in my mom's body build up and go away at irregular rate and location...
by LMighty
Thu Jul 27, 2017 12:06 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: TECENTRIQ (atezolizumab) + COTELLIC (cobimetinib) for Stage IV, starting 11/7/2017
Replies: 24
Views: 2570

Re: TECENTRIQ (atezolizumab) + COTELLIC (cobimetinib) for Stage IV, starting 11/7/2017

Hi everyone, Thank you for your kind words :) Update #3: Around 2.5 litre of ascites drained after 15 days of accumulation, and 450 ml pleural fluid after 8 days. A bit more than expected but we will take it. At worst there were 500+ ml (150+ ml) drained daily. Mom developed a mild fever yesterday a...
by LMighty
Tue Jul 25, 2017 12:48 pm
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: TECENTRIQ (atezolizumab) + COTELLIC (cobimetinib) for Stage IV, starting 11/7/2017
Replies: 24
Views: 2570

Re: TECENTRIQ (atezolizumab) + COTELLIC (cobimetinib) for Stage IV, starting 11/7/2017

Update #2: It has been 2 weeks since the start of the new regimen. Today's X-ray showed slight decrease of shadowy area in both lungs. Our onc said it's a very positive and miraculous response considering we are only 2 weeks in! Fluids seem to build up again in the lungs and abdomen but at a much sl...
by LMighty
Thu Jul 20, 2017 12:13 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: Fluid on the lung???
Replies: 6
Views: 1440

Re: Fluid on the lung???

My mom has been battling pleural effusion since last year. The fluid accumulates when the the disease grows in the pleural space. It comes back until you treat the underlying disease. A procedure called pleurodesis (https://en.wikipedia.org/wiki/Pleurodesis) may prevent its recurrence. It basically ...
by LMighty
Sat Jul 15, 2017 8:40 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: TECENTRIQ (atezolizumab) + COTELLIC (cobimetinib) for Stage IV, starting 11/7/2017
Replies: 24
Views: 2570

Re: TECENTRIQ (atezolizumab) + COTELLIC (cobimetinib) for Stage IV, starting 11/7/2017

LMighty, so happy to hear! An actual step in the right direction! Is your mom feeling more comfortable now? Not needing the drainage is itself such a relief. Yes she is. Her energy level is slowly recovering with the help of low dose of supplementary oxygen. She has intestinal cramps and mild diahh...
by LMighty
Fri Jul 14, 2017 3:49 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: TECENTRIQ (atezolizumab) + COTELLIC (cobimetinib) for Stage IV, starting 11/7/2017
Replies: 24
Views: 2570

Re: TECENTRIQ (atezolizumab) + COTELLIC (cobimetinib) for Stage IV, starting 11/7/2017

Hi everyone, Thank you so much for your kind words! I have an encouraging update. Since Wednesday the ascites reduced from 300-500ml daily to virtually zero. Not even detectable by ultrasound. Our onc said it's good news but it's too early to tell if it represents response. We will see if it stays t...
by LMighty
Tue Jul 11, 2017 9:43 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: TECENTRIQ (atezolizumab) + COTELLIC (cobimetinib) for Stage IV, starting 11/7/2017
Replies: 24
Views: 2570

Re: TECENTRIQ (atezolizumab) + COTELLIC (cobimetinib) for Stage IV, starting 11/7/2017

Hey Maia, Thanks for your concern! My mom is still in hospital for pleural fluid and ascites drainage and it has been a month. We are leaving the drains in so we can remove the fluid at home. X-rays from a few days ago showed a bit more shadow especially in the left lung. Our onc's interpretation is...
by LMighty
Tue Jul 11, 2017 3:36 am
Forum: Colon Talk - Colon cancer (colorectal cancer) support forum
Topic: TECENTRIQ (atezolizumab) + COTELLIC (cobimetinib) for Stage IV, starting 11/7/2017
Replies: 24
Views: 2570

TECENTRIQ (atezolizumab) + COTELLIC (cobimetinib) for Stage IV, starting 11/7/2017

HI everyone, With the help and support from members on this board (particularly Maia -- the info you shared is crucial!) and our VERY accommodating, supportive oncologist, treatment with TECENTRIQ (atezolizumab) + COTELLIC (cobimetinib) for my mom (stage IV, KRAS wild-type, MSS; failed Xelox + Avast...

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